What Chimpanzees Can Teach Us About Tooth Development And Weaning

For more than two decades, scientists have relied on studies that linked juvenile primate tooth development with their weaning as a rough proxy for understanding similar developmental landmarks in the evolution of early humans. New research from Harvard, however, is challenging those conclusions by showing that tooth development and weaning aren't as closely related as previously thought.

Using a first-of-its-kind method, a team of researchers led by professors Tanya Smith and Richard Wrangham and Postdoctoral Fellow Zarin Machanda of Harvard's Department of Human Evolutionary Biology used high-resolution digital photographs of chimps in the wild to show that after the eruption of their first molar tooth, many juvenile chimps continue to nurse as much, if not more, than they had in the past. Their study is described in a paper in the Proceedings of the National Academy of Sciences.

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The Eco-Dentistry Association Will Hold Industry's First Green Dentistry Conference, 3-4 May 2013, Utah

Ground-breaking event will focus on opportunities presented by high-tech, green, wellness based dentistry

The Eco-Dentistry Association® announced last week that it will hold the industry's first dental conference devoted exclusively to high-tech, environmentally sound dental practices. The event will take place May 3 and 4, 2013, at the stunning, eco-friendly Robert Redford Conference Center in Sundance, Utah, part of the Sundance Resort. Continuing Education credits will be available and attendance is limited to the first 100 registrants.

The 2013 Green Dentistry Conference™ will showcase the information and products dental professionals need to create and maintain state-of-the-art green practices. "A" List dental speakers include Gary Takacs of Takacs Learning Center, who will share the essentials of branding and marketing a green dental practice, as well as dental technology gurus Marty Jablow, DMD, Paul Feuerstein, DMD, and John Flucke, DDS who will talk about how dental technologies reduce waste and save energy, and boost the practice bottom line. With a generous sponsorship from US Bank, Bill Roth, noted sustainability author and speaker, will lead a break out group called "Green Builds Business."

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Tooth Root Formation Requires Beta-Catenin Molecule

Today, the International and American Associations for Dental Research (IADR/AADR) published a paper titled "B-catenin is Required in Odontoblasts for Tooth Root Formation." The paper, written by lead authors Tak-Heun Kim and Cheol-Hyeon Bae, Chonbuk National University Korea School of Dentistry, Laboratory for Craniofacial Biology, is published in the IADR/AADR Journal of Dental Research.

The tooth root, together with the surrounding periodontium, maintains the tooth in the jaw. The root develops after the crown forms, a process called morphogenesis. While the molecular and cellular mechanisms of early tooth development and crown morphogenesis have been extensively studied, little is known about the molecular mechanisms controlling tooth root formation.

In this study, Kim and Bae et al show that a protein called ß-catenin is strongly expressed in odontoblasts - the cells that develop the tooth dentin, and is required for root formation. Tissue-specific inactivation of ß-catenin in developing odontoblasts produced molars lacking roots and aberrantly thin incisors.

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Gingivitis Bacteria Manipulate Your Immune System So They Can Thrive In Your Gums

A new research report published in the Journal of Leukocyte Biology shows how the bacteria known for causing gum disease--Porphyromonas gingivalis--manipulates the body's immune system to disable normal processes that would otherwise destroy it. Specifically, the report shows that this pathogen prompts the production of the anti-inflammatory molecule Interleukin-10 (IL-10). This, in turn, inhibits the function of T-cells, which would otherwise help to protect the host from this particular microbial infection.

"Since greater than 50 percent of the U.S. population over 50 years-of-age develop adult periodontal disease, we hope that the results of our study will ultimately help in the development of novel treatments that could prevent or ameliorate the chronic infection caused by the pathogen P. gingivalis,'" said Jannet Katz, D.D.S., Ph.D., a researcher involved in the work from the Department of Pediatric Dentistry at the University of Alabama in Birmingham.

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Quick Detection Of Periodontitis Pathogens

Twelve million Germans suffer from periodontitis, an inflammation that can lead to the loss of teeth if left untreated. A new diagnostic platform enables the pathogens to be detected quickly, enabling dentists to act swiftly to initiate the right treatment.

Bleeding gums during tooth brushing or when biting into an apple could be an indication of periodontitis, an inflammatory disease of the tissues that surround and support the teeth. Bacterial plaque attacks the bone, meaning teeth can loosen over time and in the worst case even fall out, as they are left without a solid foundation to hold them in place. Furthermore, periodontitis also acts as a focal point from which disease can spread throughout the entire body: If the bacteria, which can be very aggressive, enter the bloodstream, they can cause further damage elsewhere. Physicians suspect there is a connection between periodontitis pathogens and the sort of cardiovascular damage that can cause heart attacks or strokes. In order to stop the source of inflammation, dentists remove dental calculus and deposits from the surface of teeth, but this is often not enough; particularly aggressive bacteria can only be eliminated with antibiotics.

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Nature-Inspired Advance For Treating Sensitive Teeth

Taking inspiration from Mother Nature, scientists are reporting an advance toward preventing the tooth sensitivity that affects millions of people around the world. Their report on development of the substance, similar to the adhesive that mussels use to attach to rocks and other surfaces in water, appears in the journal ACS Applied Materials & Interfaces.

Quan-Li Li, Chun Hung Chu and colleagues explain that about 3 out of every 4 people have teeth that are sensitive to hot, cold, sweet or sour foods and drinks. It occurs when the hard outer enamel layer on teeth and the softer underlying dentin wear away, stimulating the nerves inside. Some sugar-free gums and special toothpastes can help reduce that tooth hyper-sensitivity. However, Li and Chu cite the need for substances that rebuild both enamel and dentin at the same time. To meet that challenge, they turned to a sticky material similar to the adhesive that mussels use to adhere to surfaces. They reasoned that it could help keep minerals in contact with dentin long enough for the rebuilding process to occur.

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